"It'll build character!"
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Zqfmgb, according to Calvin, is the name of a species of worm that lives in New Guinea.
Calvin and Hobbes argue over a game of Scrabble. (February 28th, 1990)
While this species is fictional and the word is made up, Calvin uses it to presumably win a Scrabble game, as his score afterwards is 957. Hobbes tried to look up the word, but Calvin threatened to look up a twelve-letter word Hobbes played with every X and J if he did.